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Contraindicated (one)pentobarbital will lower the level or outcome of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Contraindicated (one)pentobarbital will decrease the extent or outcome of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Robust or reason